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A unified approach to mono- and disubstituted N–H indoles is described by means of oxidative cyclization of 2-alkenyl anilines, which are prepared by cross-coupling of the corresponding o-bromoanilines. This procedure is operationally expedient and tolerant of common functional groups to allow regiospecific installation of the alkyl and aryl substituents.

 

We study the design of a class of incentive mechanisms that can effectively prevent cheating in a strategic classification and regression problem. A conventional strategic classification or regression problem is modeled as a Stackelberg game, or a principal-agent problem between the designer of a classifier (the principal) and individuals subject to the classifier's decisions (the agents), potentially from different demographic groups. The former benefits from the accuracy of its decisions, whereas the latter may have an incentive to game the algorithm into making favorable but erroneous decisions. While prior works tend to focus on how to design an algorithm to be more robust to such strategic maneuvering, this study focuses on an alternative, which is to design incentive mechanisms to shape the utilities of the agents and induce effort that genuinely improves their skills, which in turn benefits both parties in the Stackelberg game. Specifically, the principal and the mechanism provider (which could also be the principal itself) move together in the first stage, publishing and committing to a classifier and an incentive mechanism. The agents are (simultaneous) second movers and best respond to the published classifier and incentive mechanism. When an agent's strategic action merely changes its observable features, it hurts the performance of the algorithm. However, if the action leads to improvement in the agent's true label, it not only helps the agent achieve better decision outcomes, but also preserves the performance of the algorithm. We study how a subsidy mechanism can induce improvement actions, positively impact a number of social well-being metrics, such as the overall skill levels of the agents (efficiency) and positive or true positive rate differences between different demographic groups (fairness). 

Network games provide a natural machinery to compactly represent strategic interactions among agents whose payoffs exhibit sparsity in their dependence on the actions of others. Besides encoding interaction sparsity, however, real networks often exhibit a multi-scale structure, in which agents can be grouped into communities, those communities further grouped, and so on, and where interactions among such groups may also exhibit sparsity. We present a general model of multi-scale network games that encodes such multi-level structure. We then develop several algorithmic approaches that leverage this multi-scale structure, and derive sufficient conditions for convergence of these to a Nash equilibrium. Our numerical experiments demonstrate that the proposed approaches enable orders of magnitude improvements in scalability when computing Nash equilibria in such games. For example, we can solve previously intractable instances involving up to 1 million agents in under 15 minutes. 

We study games with nonlinear best response functions played on a network consisting of disjoint communities. Prior works on network games have identified conditions to guarantee the uniqueness and stability of Nash equilibria in a network without any community structure. In this paper we are interested in accomplishing the same for networks with a community structure; it turns out that these conditions are much easier to verify with certain community structures. Specifically, we consider multipartite graphs and show that the uniqueness and stability of Nash equilibria are related to matrices which are potentially much lower in dimension, on the order of the number of communities, compared to same-size networks without a multipartite structure, in which case such matrices have a dimension the size of the network. We further introduce a new notion of degree centrality to measure the importance and influence of a community in such a network. We show that this notion enables us to find new conditions for uniqueness and stability of Nash equilibria. 

How predictable are life trajectories? We investigated this question with a scientific mass collaboration using the common task method; 160 teams built predictive models for six life outcomes using data from the Fragile Families and Child Wellbeing Study, a high-quality birth cohort study. Despite using a rich dataset and applying machine-learning methods optimized for prediction, the best predictions were not very accurate and were only slightly better than those from a simple benchmark model. Within each outcome, prediction error was strongly associated with the family being predicted and weakly associated with the technique used to generate the prediction. Overall, these results suggest practical limits to the predictability of life outcomes in some settings and illustrate the value of mass collaborations in the social sciences.